Cape Aloe

Cape aloe has been used historically to promote healthy elimination. Cape aloe is one of a class of compounds called anthraquinone glycosides. Per the European Medicines Agency (EMA), cape aloe possesses two different mechanisms of action as a laxative: 1) stimulation of the motility of the large intestine, resulting in accelerated colonic transit; and 2) influence on secretion processes by two concomitant mechanisms (absorption of water and electrolytes into the colonic epithelial environment and increase of the leakiness of the tight junctions, and simulation of secretion of water and electrolytes into the lumen of the colon). When ingested, cape aloe molecules are activated through bacterial metabolism in the gut. They promote water retention in the stool and stimulate peristalsis in the large intestine. By stimulating active chloride secretion, aloe increases the water and electrolyte content in the stool and eases its passage without the artificial additives.

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Clinical Applications

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